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Exploring Testosterone Creams vs. Injections -What's Right for You?

Written by

Science & Humans

Medically approved by

Maria Jacob

Last updated

Monday, August 2, 2021

While both testosterone creams and testosterone injections are effective in treating low-T or hypogonadism symptoms, improving muscle mass and strength, sense of well being, sexual function and cognitive ability, the choice of delivery is dependent on lifestyle, and what is comfortable for the patient using testosterone therapy.

Discussing existing comorbidities like diabetes, hypertension, cardiovascular issues, any medications and supplements like vitamins used, among other medically relevant details with a therapist before starting testosterone therapy is important.

Oral testosterone may cause liver issues and patches have been known to cause severe skin rashes and welts. Here’s what one needs to know to make an informed choice.

What does TRT (Testosterone Replacement Therapy) do?

TRT therapy is about treating symptoms of hypogonadism.
  1. Erectile Dysfunction (ED)
  2. Low sperm count
  3. Depressed mood
  4. Decreased libido
  5. Reduced muscle tone and strength
  6. Sleep disturbances
  7. Loss of hair



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This allows our medical team to analyse your blood test and confirm if you’ve qualified for treatment


How is Low-T (Hypogonadism) diagnosed and treated?

Qualification for TRT therapy has to be determined by a doctor starting with a simple blood test and consultation. Only after determining if TRT is suitable, medication is prescribed and monitored to fine tune correct dosage. There is no cookie-cutter dosage and it has to be tailored for individual needs taking into consideration other medical issues, if any. Results can be seen in a couple of months.


Compared to the downside of low testosterone, the risks of supplementing T is highly acceptable. Testosterone Creams

Endocrinologists mostly recommend creams since testosterone is released at a constant rate, preventing peaks and valleys that are typical to injections. Painless and application is easy. Topical T is applied to shoulders, forearms, or inner thighs.​

For beginners this is a benefit as it avoids scar tissue formation, buying syringes, frequent office visits for injections if not self-injecting etc. Applying cream at the same time everyday and following instructions, diligently washing hands after application and not touching others is important.​

Creams come in single dose tubes or dispensers that release precise dosage.​

Bioavailability is higher with creams. Erectile strength and sexual functioning is boosted due to enhanced dihydrotestosterone release.​

Creams have to be applied on clean dry skin and it has to be absorbed fully (typically takes up to 90 minutes) before showering, indulging in any physical activity that will induce sweating, or coming into contact with others including pregnant women and children to avoid contamination risk.

Testosterone Injections

Injections are the earliest form of TRT therapy and are affordable and dependable. Using injections means you need frequent doctor visits and monitoring since injections have a higher risk of enlarged prostate and higher red blood cell counts. They are easy for those who cannot be consistent with daily application.

Testosterone injections build slightly better muscle mass and enhance strength far more than the cream. This is also independent of how active a person is.

If self-injecting, syringes, needles and other consumables have to be bought. You may also experience a formation of scar tissue since injection therapy is prolonged or even life-time.

Injection dosage is higher than gels which raises testosterone levels in blood quickly before depleting to base-line. You may notice that fluctuating T-levels affect the mood.

Further reading

Testosterone Cypionate versus Testosterone Enanthate

Testosterone Cypionate versus Testosterone Enanthate

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Which Testosterone Cream is Safe for Scrotal Application?

Which Testosterone Cream is Safe for Scrotal Application?

Custom testosterone cream for scrotal application has advantages, such as customized dosage, faster absorption, and convenience, but DHT and PSA levels must be monitored ...

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Differences Between Testosterone Enanthate and XYOSTED

Differences Between Testosterone Enanthate and XYOSTED

Testosterone enanthate and Xyosted are injections used to treat hypogonadism, testosterone deficiencies, and FTM transition, but differ in dosage and frequency. Xyosted i ...

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