Differences Between Testosterone Enanthate and XYOSTED

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Science & Humans

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Medically approved by

Maria Jacob

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Differences Between Testosterone Enanthate and XYOSTED

Testosterone enanthate is generic that costs less, injected intramuscularly, usually deep into buttock muscles. Or thighs if self injecting, contains preservatives like benzyl benzoate, or benzyl alcohol and available in multi-use doses and single use ampoules. Frequency – daily, weekly, bi-weekly or monthly.

Xyosted is branded testosterone enanthate is a weekly, pre-filled single dose auto-injector, injected subcutaneously (under the skin - stomach), costs more. FDA approved for single use only and does not contain preservatives.

Both testosterone enanthate and Xyosted are testosterone injections that treat symptoms of hypogonadism, testosterone deficiencies from other medical conditions, FTM transition. Body builders also use testosterone enanthate to increase muscle mass. It is illegal for athletes to use such steroids to boost performance.

How does Dosage differ?

Xyosted cis available only as single use auto injector in standard 50mg/0.5mL, 75mg/0.5ml, and 100mg/0.5ml concentration without any preservatives, administered weekly..

Enanthate comes in single use ampoules and *multi dose vials with a preservative. The actual dosage prescribed differs based on several parameters including micro dosing.

Micro dosing would mean taking injections daily to mimic natural testosterone production to avoid peaks and valleys.

The frequency and dosage both can differ from person to person, as such there is no standard dosage.

*Multi-dose vials should be used only for one patient and never shared with another person. The CDC has good info on protocols of using multi-use vials. 


While both medications start working immediately, it takes about 6 weeks for testosterone levels to stabilize. So it is essential to wait for at least 6 weeks to determine if change in dosage or frequency or both is required. It might take a few months to find the right dosage that works

Since generic enanthate is intra-muscular, effect on muscles is seen faster while subcutaneous xyosted will show faster results in sexual drive, erections that lasts longer.



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Enanthate vs Xyosted – Side Effects

Testosterone Enanthate generic has been used for a long time and side effects are minimal and highly manageable.

Allergies to the preservative or the oil used, may cause itching and bruising, swelling, lumps around the injection site. Xyosted is only sesame oil based whereas, generic testosterone enanthate comes in different oils like cotton seed, peanut oil, sesame oil, olive oil etc.

Changing injection sites is important, this also prevents bruising of the surrounding tissue from frequent injections.

Xyosted should not be injected into muscle or vein since the body cannot metabolize it this way. It has to be only under the skin. Care should be taken not to use xposed on scars or bruised sites as this will result in uneven absorption.

Risk of abuse may be higher in xyosted, more blood tests than generic testosterone enanthate at regular intervals are necessary with xyosted to monitor testosterone & nutrient levels.

The most common side effects of XYOSTED include: red blood cell increase, prostatic specific antigen (PSA) increase (a blood test for prostate cancer), increased blood pressure, and injection site reactions including bruising, bleeding, redness and headache.

Other side effects include more erections than are normal for you or erections that last a long time. More side effects for xyosted can be found on their website.

Xyosted cannot be used for following:

  • LIf you are a man who has breast cancer
  • Have or might have prostate cancer
  • Are a woman who is pregnant. It may harm your unborn baby
  • Allergic to testosterone or sesame oil
  • Have low testosterone without certain medical conditions. For example, low testosterone levels due to old age.

Very important to inform the doctor about following:

High blood pressure or heart problems, high red blood cell count, urinary problems due to an enlarged prostate, kidney or liver problems, a history of mental health illness including suicidal thoughts or actions, depression, anxiety or mood disorder, or problems breathing while you sleep (sleep apnea).

Using XYOSTED with other medicines can affect each other. Especially, tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), corticosteroids or medicines for pain and cold.

It is important to disclose medical conditions, prescription meds taken, and vitamins, supplements - herbal or otherwise during consultation to determine suitability for TRT therapy. You can ask the pharmacist for a list of medications if you are not sure.

It is always good practice to have such a list while consulting and also show to pharmacists whenever new meds are prescribed.

A good faq + protocol for multi-dose medication: Visit CDC GOV

A detailed medical history is taken at Science&Human to make sure contraindications & allergies, other health conditions and medications used are harmonious and do not cause problems.

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