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Human Chorionic Gonadotropin and TRT: The Relationship Explained

Written by

Science & Humans

Medically approved by

Maria Jacob

Last updated

Thursday, September 1, 2022

Prevents Testicular Atrophy

Disruption of the Hypothalamic Pitutiary Gonadal Axis (HPG Axis) due to external testosterone replacement creates a negative loop back reducing synthesis of Lutenizing Hormone(LH) and Follicle Stimulating Hormone (FSH) which affects spermatogenesis, and natural testosterone production in the testes. This also leads to shriveling of the testes known as testicular atrophy. Human Chorionic Gonadotrophin (hCG) counters testicular atrophy by mimicking lutenizing hormone which stimulates the leydig cells to synthesize testosterone in the testes, which keeps the natural testosterone production on going preventing testicular atrophy.

Testicular atrophy can be painful and whether one seeks to have children or not, a TRT therapy protocol combining HCG is beneficial to keep the testicular functioning as nature intended.

Improved Libido and Change in Penis Size

Testicular function not being impaired due to Human Chorionic Gonadotrophin (HCG) with supplementation of testosterone has a pleasant outcome of also improving sex drive. It also restores size of penis and improves sensitivity.

TRT therapy with HCG is beneficial both ways – combining during trt therapy, and after stopping trt therapy for progeny:

Improved Fertility

External testosterone interferes with intra-testicular testosterone production which creates a cascading effect on leydig cells and sertolli cells due to suppression of LH and FSH. Both are crucial for spermatogenesis.

With HCG acting like LH, testicular testosterone production will keep up, along with sertolli cells cranking the sperm factory.

Improved sperm generation and mobility beneficial for those wanting children while on TRT therapy.

The type of hypogonadism, primary or secondary also determines outcomes to HCG. If primary hypogonadism is the cause which is testicular, efficacy might be limited in terms of fertility. However it is not a big concern since it does not mean testicular production of testosterone is fully stopped.



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Enable Sperm Generation after Stopping TRT Therapy

HCG helps stimulates the leydig cells to resume testicular testosterone production, and sertolli cells to produce sperm, which might be reduced or fully impaired due to suppressed LH and FSH.

Age, and the length of TRT therapy one was on before stopping for progeny, determines the extent spermatogenesis including the quality of the sperm in terms of motility is impaired.

TRT induced infertility naturally reverses on stopping therapy in most cases. Human Chorionic Gonadotrophin helps to regain lost ground pretty quickly in terms of both sperm generation and motility of sperm.

Quite a few studies have demonstrated how HCG has helped reverse infertility after TRT. Even in severe cases where spermatogenesis is fully stopped due to heavy use of testosterone, for example - body builders both sperm generation and quality of sperm including motility has been restored after a few months of treatment, leading to natural conception.

Stabilizing Testosterone Levels Avoiding Peaks and Troughs

A daily injection of a small dose of HCG sub-cutaneously avoids estrogen spikes typically caused with external testosterone. Bigger the dosage of testosterone ester administered, bigger the testosterone and oestradiol spike due to a process called aromotization. Oestradiol is the predecessor to estrogen.

Increased estrogen synthesis can lead to gynecomastia, water retention or edema, increased body fat.

Estrogen is also an essential hormone in men which regulates cognition, intelligence. But over stimulation is counter productive.

The endocrinologist will monitor different hormone levels, after a detailed blood work and determine correct dosage. Ideally better to start with the smallest testosterone dose, and then increase which results in optimum hormonal levels.

Starting off with bigger doses of testosterone is not ideal hormone replacement therapy. Such testosterone abuse leads to many health issues down the road. Which is why TRT therapy always should be prescribed and monitored by qualified physcian after thorough blood work.

Further reading

Hypogonadism or Low-T in Younger Men and Testosterone Intervention

Hypogonadism or Low-T in Younger Men and Testosterone Intervention

Genital or acquired disorders can cause weariness and a lack of energy, while testosterone and HCG can help raise T levels without compromising sperm production, but exte ...

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What is Human Growth Hormone (HGH)?

What is Human Growth Hormone (HGH)?

HGH therapy is a hormone used to replenish low levels of body composition, cell growth, and growth. TRT is a steroidal hormone that increases libido and muscle mass. Ther ...

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Guide on Fertility, Testosterone and hCG How it helps ?

Guide on Fertility, Testosterone and hCG How it helps ?

HCG can help increase testosterone and hypogonadism in men with low testosterone levels, potentially increasing fertility. It can be used as an alternative or in conjunct ...

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