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TRT and Weight Loss: Does Testosterone Therapy helps in Weight loss ?

Written by

Science & Humans

Medically approved by

Maria Jacob

Last updated

Friday, June 30, 2023

TRT and Weight Loss: The Truth About Testosterone Replacement Therapy and Shedding Pounds

Are you struggling to lose weight despite your efforts to maintain a healthy diet and exercise regularly? This may be due to low testosterone levels. Testosterone, the primary male sex hormone, is crucial for maintaining muscle mass, bone density, and strength. It also affects mood, sleep, and sex drive (1). When testosterone levels drop, it can lead to weight gain, particularly in the form of fat mass, and a decrease in muscle mass.

Testosterone replacement therapy (TRT) might help you lose weight by increasing your testosterone levels. Studies have shown that TRT can help men not only lose weight but keep the weight off (1). TRT can also improve insulin sensitivity, glucose homeostasis, and resting energy expenditure, which can further aid in weight loss. However, TRT is not a magic solution for weight loss, and it should not be used solely for this purpose (1,2). A balanced diet, calorie deficit, and physical activity are still important for weight loss.

What is TRT?

If you're struggling with weight loss and have low testosterone levels, TRT may be a solution for you. TRT stands for testosterone replacement therapy, and it's a treatment that involves increasing your testosterone levels with injections or cream.

Testosterone is a hormone that is primarily produced in the testicles in men and adrenal glands in women (1,2). It plays a crucial role in the development of male reproductive tissues, such as the testicles and prostate, as well as secondary sexual characteristics like facial and body hair.

Low testosterone levels can lead to a variety of symptoms, including decreased sex drive, erectile dysfunction, fatigue, and decreased muscle mass. In some cases, low testosterone can also lead to male hypogonadism, a condition in which the testicles don't produce enough testosterone. TRT involves replacing the testosterone that your body is not producing enough of. This can be done through injections, patches, or cream. Injections are the most common form of TRT and involve injecting testosterone into the muscle every two to four weeks. Creams are also available and can be applied to the skin daily.

While TRT can be an effective treatment for low testosterone levels, it's important to note that it's not without risks. TRT can increase the risk of prostate cancer, blood clots, and skin irritation from patches and cream (1,2). It's important to discuss the risks and benefits of TRT with your doctor before starting treatment.



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TRT and Weight Loss

If you're struggling to lose weight, you may have heard about testosterone replacement therapy (TRT) as a possible solution. But can TRT really help you lose weight? Let's take a closer look.

TRT and Fat Loss

One of the main ways TRT can help with weight loss is by reducing fat mass. Testosterone plays a key role in regulating fat metabolism, and low testosterone levels have been linked to increased body fat and obesity. By increasing your testosterone levels through TRT, you may be able to reduce your body fat and achieve a leaner physique.

TRT and Muscle Mass

Another way TRT can help with weight loss is by increasing muscle mass. Testosterone is essential for the development and maintenance of skeletal muscle mass, and low testosterone levels can lead to muscle loss and weakness. By increasing your testosterone levels through TRT and engaging in strength training exercises, you may be able to build more muscle and increase your metabolic rate, which can help you burn more calories and lose weight.

TRT and Metabolism

TRT can also help with weight loss by improving your metabolism. Testosterone plays a role in regulating resting energy expenditure, insulin sensitivity, and glucose homeostasis, all of which are important factors in weight management(3). By increasing your testosterone levels through TRT, you may be able to improve your metabolism and burn more calories, even at rest.

It's important to note that TRT is not a magic solution for weight loss. To see results, you'll need to combine TRT with other healthy habits, such as a balanced diet and regular physical activity. TRT should also be used under the guidance of a qualified healthcare provider, as it can have potential side effects and risks, such as prostate cancer and blood clots.

In summary, TRT can potentially help with weight loss by reducing fat mass, increasing muscle mass, and improving metabolism. However, it should be used as part of a comprehensive weight loss plan and under the guidance of a healthcare provider.

Frequently Asked Questions

What is the average weight loss on TRT?

The average weight loss on TRT varies from person to person. It depends on factors such as your starting weight, age, and lifestyle habits. Some patients may lose a few pounds, while others may lose significant weight (5). However, it is important to note that TRT is not a weight loss treatment. Its primary purpose is to treat and supplement low testosterone levels.

How long does it take to lose weight on testosterone?

The length of time it takes to lose weight on testosterone varies. Some people may see results within a few weeks, while others may take several months (4). It is important to remember that TRT is not a quick fix for weight loss. It is a long-term treatment that requires commitment and lifestyle changes.

Can testosterone help with weight loss in females?

Testosterone replacement therapy is primarily used to treat low testosterone levels in men. However, some women may also benefit from TRT. Testosterone can help increase muscle mass and decrease body fat, which can lead to weight loss. However, it is important to consult with a medical professional to determine if TRT is right for you.

Why am I not losing weight on TRT?

If you are not losing weight on TRT, there could be several reasons. It could be due to a lack of exercise or unhealthy eating habits. It is important to maintain a healthy lifestyle while on TRT to see the best results. Additionally, it is important to consult with your healthcare provider to ensure that your testosterone levels are properly balanced.

What is the best testosterone for weight loss?

There is no one "best" testosterone for weight loss. Different types of testosterone replacement therapy may work better for different people. It is important to consult with a medical professional to determine the best course of treatment for your individual needs.

How much does losing weight increase testosterone?

Losing weight can help increase testosterone levels(3-5). When you lose weight, your body fat percentage decreases, which can help increase testosterone levels. However, the amount of increase varies from person to person. It is important to maintain a healthy lifestyle to see the best results.


1. Antonio L, Wu FC, O'Neill TW, Pye SR, Ahern TB, Laurent MR, Huhtaniemi IT, Lean ME, Keevil BG, Rastrelli G, Forti G. Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone. The Journal of Clinical Endocrinology & Metabolism. 2016 Jul 1;101(7):2647-57. https://doi.org/10.1210/jc.2015-4106

2. Zitzmann M, Nieschlag E. Testosterone replacement therapy: current trends and future directions. Hum Reprod Update. 2004;10(5):409-419. Available from: https://pubmed.ncbi.nlm.nih.gov/15297434/

3. Mårin P. Testosterone and regional fat distribution. Obesity research. 1995 Nov;3(S4):609S-12S. https://doi.org/10.1002/j.1550-8528.1995.tb00233.x

4.Traish AM. Testosterone and weight loss: the evidence. Current opinion in endocrinology, diabetes, and obesity. 2014 Oct;21(5):313.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154787/

5. Saad F, Yassin A, Doros G, Haider A. Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies. International journal of obesity. 2016 Jan;40(1):162-70. https://www.nature.com/articles/ijo2015139

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