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Rybelsus vs. Ozempic: Which Medication is Right for You?

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Science and Humans

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Maria Jacob

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Rybelsus vs. Ozempic: Which Medication is Right for You?

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Rybelsus and Ozempic are both options commonly discussed in the treatment of type 2 diabetes and are also used in weight management programs. While they contain the same active ingredient, they differ in format, dosage frequency, and price—factors that may impact your personal preference and treatment plan.

At a Glance: Rybelsus vs Ozempic

FeatureRybelsusOzempic
FormOral tabletPrefilled pen
FrequencyOnce dailyOnce weekly
Available Doses3 mg, 7 mg, 14 mg0.25 mg, 0.5 mg, 1 mg, 2 mg
Pen SizesNot applicablePen options vary by dose
Retail Price Range (CAD)$800–$900/month$800–$1,000/month
Program AccessOffered through Science & Humans' virtual care model, with eligibility screening required 

Cost and Access in Canada

Both medications are available in Canada through programs like Science & Humans, which offer virtual assessments with licensed providers. The price for a 4-week supply typically ranges from $800 to $1,000, depending on the dose selected. Your final cost may be reduced if you have private insurance or access to a manufacturer savings program.

What to Consider When Choosing

  • Format Preference: Rybelsus may be preferable if you’re more comfortable with oral tablets, while Ozempic offers once-weekly dosing convenience with prefilled pens.
  • Consistency: Some individuals find it easier to remember a weekly schedule vs. a daily one—or vice versa.
  • Lifestyle Fit: Depending on your daily routine and comfort with specific formats, one may fit better into your lifestyle.

Talk to a Healthcare Professional

Choosing the right option depends on your health goals, lifestyle, and preferences. At Science & Humans, our clinical team will review your medical history, provide a requisition for blood work, and help determine the most appropriate plan for you.

Explore Our Programs

Whether you're new to these options or considering a switch, our weight loss and hormone optimization programs offer:

  • Comprehensive blood work (covered by your health card at the lab, where applicable)
  • A $100 consultation with a licensed nurse practitioner (non-refundable, may be covered by private insurance)
  • Ongoing support, coaching, and prescription management
  • Access to Canadian-licensed pharmacies

 

Disclaimer

This content is intended for educational purposes only and should not be interpreted as medical advice. Always consult a licensed healthcare provider for personalized recommendations.

 

Frequently Asked Questions about Ozempic and Rybelsus

Is Rybelsus the same as Ozempic?

While both Rybelsus and Ozempic contain the active ingredient semaglutide and belong to the same class of medications (GLP-1 receptor agonists), they differ in form and administration. Rybelsus is an oral tablet taken daily, whereas Ozempic is an injectable taken weekly .

Is Rybelsus Cheaper than Ozempic in Canada?

The cost of Rybelsus and Ozempic can vary based on location, insurance coverage, and other factors. In general, Rybelsus tends to be slightly more affordable than Ozempic. However, it's essential to check with local pharmacies and insurance providers for specific pricing and coverage details in Canada .

Can you switch from Rybelsus 14 mg to Ozempic?

Switching between Rybelsus and Ozempic should be done under the guidance of a healthcare provider. They can help you transition safely and monitor your response to the new medication. Factors such as dosage adjustments, potential side effects, and overall treatment goals should be considered during the switch.

Is Rybelsus better than Ozempic for Weight Loss?

Clinical studies have shown that Ozempic generally leads to more significant weight loss compared to Rybelsus. However, individual results can vary, and other factors such as personal preferences, lifestyle, and overall health should be considered when choosing a medication.

Has Rybelsus Been Approved for Weight Loss in Canada?

As of now, Rybelsus is primarily approved for the treatment of type 2 diabetes. It is not specifically approved for weight loss. However, weight loss can be a beneficial side effect for many patients. For updates on approvals, consult local health authorities or your healthcare provider.

References:

  • Aroda, V. R., Aberle, J., Lars Bardtrum, Christiansen, E., Knop, F. K., Sanaz Gabery, Pedersen, S. D., & Buse, J. B. (2023). Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial. Lancet, 402(10403), 693–704. https://doi.org/10.1016/s0140-6736(23)01127-3

  • Billingsley, A. (2023, July 4). Rybelsus for Weight Loss: 5 Things to Know about Oral Ozempic. GoodRx; GoodRx. https://www.goodrx.com/conditions/weight-loss/rybelsus-weight-loss

  • Rybelsus for Weight Loss: Does It Work? (n.d.). Ro. Retrieved July 20, 2024, from https://ro.co/weight-loss/rybelsus-weight-loss/

  • V.R. Aroda, Ahmann, A., B. Cariou, Chow, F., Davies, M. J., E. Jódar, Mehta, R., Woo, V., & I. Lingvay. (2019). Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1–7 trials. Diabetes & Metabolism, 45(5), 409–418. https://doi.org/10.1016/j.diabet.2018.12.001

  • John P.H. Wilding, Batterham, R. L., Calanna, S., Davies, M., Gaal, van, Ildiko Lingvay, McGowan, B. M., Rosenstock, J., Marie T.D. Tran, Wadden, T. A., Wharton, S., Koutaro Yokote, Niels Zeuthen, & Kushner, R. F. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine/the New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/nejmoa2032183

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