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Liraglutide vs Semaglutide: Key Facts and Differences Explained

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Maria Jacob

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Liraglutide vs Semaglutide: Key Facts and Differences Explained

Read in 30s...
  • Liraglutide and semaglutide are prescription medications approved in Canada for type 2 diabetes management, with certain formulations also approved for chronic weight management.
  • Both are available under different brand names and doses.
  • Differences between them include dosing frequency, approved uses, and available strengths.
  • Costs and insurance coverage can vary.
  • Your healthcare provider can help determine the best fit for your needs.

Introduction

In Canada, both liraglutide and semaglutide are prescribed to help manage type 2 diabetes, and some formulations are approved for chronic weight management. While these medications share similarities, there are differences in their approved uses, dosing schedules, and available strengths. Understanding these distinctions can help you have a more informed conversation with your healthcare provider.

Approved Uses in Canada

Liraglutide

  • Approved for type 2 diabetes management in adults to help improve blood sugar control.
  • Certain higher-dose formulations are approved for chronic weight management in adults with obesity or overweight and at least one weight-related health condition.

Semaglutide

  • Approved for type 2 diabetes management in adults, alongside diet and exercise, to improve blood sugar control.
  • Certain higher-dose formulations are approved for chronic weight management in adults meeting specific health criteria.

Dosage and Strengths

While both medications are available in multiple strengths, the dosing schedules differ.

  • Liraglutide is typically taken more frequently, whereas semaglutide is taken less often.
  • The starting dose and titration schedule will be determined by your healthcare provider.

Important: Only a licensed healthcare professional can decide the appropriate medication, dose, and schedule for you, based on your medical history and treatment goals.

Cost and Coverage in Canada

The cost of liraglutide and semaglutide in Canada can vary depending on:

  • Formulation and dose prescribed
  • Whether you have private insurance coverage
  • Pharmacy dispensing fees

Some private insurance plans and provincial drug benefit programs may cover one or both medications, but coverage requirements differ. Your healthcare provider or pharmacist can help you check eligibility.

Choosing Between Liraglutide and Semaglutide

There is no one-size-fits-all answer. The choice may depend on:

  • Your health profile and treatment goals
  • How often you prefer to take your medication
  • Cost and insurance coverage
  • Your response to previous treatments

Your healthcare provider will review your medical history, current health status, and preferences before recommending an option.

The Bottom Line

Both liraglutide and semaglutide can play a role in managing type 2 diabetes, and certain formulations are also approved for chronic weight management in Canada. Deciding which is right for you should always be done in consultation with a healthcare provider, who can tailor a treatment plan to your needs.

 

Disclaimer

This content is intended for educational purposes only and should not be interpreted as medical advice. Always consult a licensed healthcare provider for personalized recommendations.

 

Frequently Asked Questions about Liraglutide and Semaglutide

Is liraglutide better than semaglutide?

According to the STEP 1 and SCALE trial comparison, semaglutide seems to have an overall better cost-affect ratio than liraglutide.

Is semaglutide stronger than Saxenda?

Semaglutide is proven to be slightly more efficient at weight loss and diabetes management than liraglutide. As Saxenda is a liraglutide, yes semaglutide is stronger than Saxenda. The efficacy also depends on an individual’s lifestyle and health condition.

Can I switch from liraglutide to semaglutide?

It is possible to switch from one medication to the other. If the side effects of one medication are too strong or if you don’t see any significant effect of the drug, then you can consult your doctor and suggest a switch. You must remember when your last dose was, and try not to lose many doses before making the switch.

Why am I not losing more weight on semaglutide?

There could be many reasons why a certain medication is not working out for you. First of all, you must ensure that you are eating a low-calorie diet consistently and you exercise every day. If even with the lifestyle changes a drug does not work for you, you can switch to the medication. Remember that it is a slow and long process, so it may take some time before you see significant difference.

Does everyone gain weight back after semaglutide?

It is quite common to gain weight back after stopping semaglutide (or any kind of GLP-1 agonist). Ensure that you keep exercising and consuming the same low-calorie diet to manage your body weight.

Can I stay on semaglutide forever?

The exact duration of your medication may depend on your needs, health conditions, etc. Typically, as semaglutide is meant for long-term usage, patients take it up to 2 years. You don’t have to stick to it, but it is not advised to suddenly stop taking your dose either. If you finish to keep taking or stop taking a drug, consult your doctor.

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