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Can You Stop Testosterone Therapy Once You Start

Written by

Science & Humans

Medically approved by

Maria Jacob

Last updated

Friday, July 14, 2023

Can You Stop Testosterone Therapy Once You Start?

If you're considering testosterone therapy, you may be wondering what will happen if you decide to stop. The short answer is yes, you can stop testosterone therapy, but there are a number of factors to consider. Testosterone therapy can be used to treat a variety of conditions, such as low testosterone levels, delayed puberty, and gender dysphoria.   However, once you start testosterone therapy, your body will depend on it to function properly.

If you suddenly stop taking testosterone, your body may experience a low testosterone level and may go into withdrawal (1). This can cause a range of symptoms, such as fatigue, depression, decreased sex drive, and hot flashes. However, there are safe ways to stop testosterone therapy, and it's important to work with your healthcare provider to develop a plan that's right for you.

Potential Risks and Side Effects of Stopping Testosterone Therapy

If you are considering stopping testosterone therapy, it is important to understand the potential risks and side effects. Suddenly stopping testosterone therapy, also known as "cold turkey," can result in harsh side effects (1), especially if your starting testosterone levels were extremely low.  

Increased Risk of Blood Clots

Stopping testosterone therapy can decrease the risk of blood clots (2). While testosterone helps to maintain healthy blood flow and circulation, and high levels of testosterone can cause blood clots. If you experience any unusual swelling or pain in your legs while using TRT, please seek medical attention immediately.

Cardiovascular Disease and Heart Attack

Low testosterone levels are associated with an increased risk of cardiovascular disease and heart attack (3). Testosterone therapy can help to reduce this risk, but stopping testosterone therapy can increase the risk again. It is important to consult with your healthcare provider before stopping testosterone therapy.

Thinning Hair and Oily Skin

Testosterone therapy can help to improve hair growth and reduce oily skin. Stopping testosterone therapy can result in thinning hair and increased oiliness of the skin (4) .

Mood Swings and Depression

Low testosterone levels can cause mood swings and depression.   Testosterone therapy can help to improve mood and reduce depression, but stopping testosterone therapy can cause these symptoms to return (4).

Loss of Muscle Mass and Strength

Testosterone therapy can help to increase muscle mass and strength.  Stopping testosterone therapy can result in a loss of muscle mass and strength.

Fatigue and Low Energy Levels

Low testosterone levels can cause fatigue and low energy levels. Testosterone therapy can help to improve energy levels, but stopping testosterone therapy can cause fatigue and low energy levels to return (1,4).

Decreased Sexual Function and Libido

Low testosterone levels can cause decreased sexual function and libido. Testosterone therapy can help to improve sexual function and libido, but stopping testosterone therapy can cause these symptoms to return.  

It is important to consult with your healthcare provider before stopping testosterone therapy. Your healthcare provider can help you to develop a plan for weaning off testosterone therapy to minimize the risk of side effects and withdrawal symptoms.

Factors to Consider Before Stopping Testosterone Therapy

If you are considering stopping testosterone therapy, there are several factors to consider before making a decision. It is important to understand the potential risks and benefits of stopping testosterone therapy and to consult with your healthcare provider to determine the best course of action for your individual needs.

Consulting with Your Healthcare Provider

Before stopping testosterone therapy, it is important to consult with your healthcare provider. Your healthcare provider can help you determine the best course of action based on your individual needs. They can also help you develop a plan for gradually weaning off of testosterone therapy to minimize any potential side effects.

Gradual Weaning Off of Testosterone Therapy

If you decide to stop testosterone therapy, it is important to gradually wean off of the treatment. Abruptly stopping testosterone therapy can cause unpleasant symptoms such as fatigue, depression, and decreased libido (1). Gradually tapering off of testosterone therapy can help minimize these symptoms and make the transition smoother.

Exploring Alternative Treatment Options

If you are stopping testosterone therapy due to side effects or other concerns, it may be helpful to explore alternative treatment options. Some alternatives to testosterone therapy include human chorionic gonadotropin (HCG) therapy, which can help stimulate natural testosterone production, and lifestyle changes such as exercise and a healthy diet.

In conclusion, stoppifng testosterone therapy is a decision that should be made in consultation with your healthcare provider. Gradually weaning off of testosterone therapy and exploring alternative treatment options can help minimize any potential side effects and make the transition smoother.

Potential Consequences of Abruptly Stopping Testosterone Therapy

If you are considering stopping testosterone therapy, it is important to understand the potential consequences of doing so (1). Abruptly stopping testosterone therapy can lead to a range of negative effects on your health and well-being.

Withdrawal Symptoms

One of the most significant consequences of stopping testosterone therapy is the onset of withdrawal symptoms (1). These symptoms can include fatigue, mood swings, depression, and decreased libido. Additionally, stopping testosterone therapy can cause a decrease in muscle mass, an increase in body fat, and a decrease in strength.

Negative Impact on Mood and Energy Levels

Stopping testosterone therapy can also have a negative impact on your mood and energy levels. Testosterone plays a key role in regulating mood and energy, and stopping therapy can lead to a decrease in both. You may experience feelings of fatigue, irritability, and a lack of motivation.

Changes in Body Composition and Sexual Function

Testosterone therapy is often used to improve sexual function and body composition, and stopping therapy can lead to a reversal of these benefits. You may experience a decrease in libido, erectile dysfunction, and a decrease in muscle mass. Additionally, stopping therapy can lead to an increase in body fat and a decrease in strength.

In conclusion, stopping testosterone therapy can have a range of negative consequences on your health and well-being. It is important to speak with your healthcare provider before making any changes to your testosterone therapy regimen. They can help you develop a plan that minimizes the risk of negative side effects and ensures that you maintain optimal health and well-being.

Monitoring Testosterone Levels After Stopping Testosterone Therapy

If you have decided to stop testosterone therapy, it is important to monitor your testosterone levels to ensure that they return to normal. Here are some ways to monitor your testosterone levels after stopping testosterone therapy.

Blood Tests

Your healthcare provider may recommend regular blood tests to monitor your testosterone levels after stopping testosterone therapy. Blood tests can help determine whether your testosterone levels have returned to normal or if you are experiencing low testosterone levels.

Symptoms of Low Testosterone

It is important to be aware of the symptoms of low testosterone, which can include fatigue, decreased libido, decreased muscle mass, and decreased bone density (1,4). If you experience any of these symptoms after stopping testosterone therapy, it is important to talk to your healthcare provider.

In addition to monitoring your testosterone levels and symptoms, it is important to maintain a healthy lifestyle after stopping testosterone therapy. This includes eating a healthy diet, exercising regularly, and getting enough sleep.

Remember that stopping testosterone therapy can have different effects on different people. It is important to work with your healthcare provider to determine the best course of action for you.

 

References

  • Yassin A, Nettleship JE, Talib RA, Almehmadi Y, Doros G. Effects of testosterone replacement therapy withdrawal and re-treatment in hypogonadal elderly men upon obesity, voiding function and prostate safety parameters. The Aging Male. 2016 Jan 2;19(1):64-9. https://doi.org/10.3109/13685538.2015.1126573.
  • Sharma R, Oni OA, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Barua RS, Gupta K. Association between testosterone replacement therapy and the incidence of DVT and pulmonary embolism: a retrospective cohort study of the Veterans Administration Database. Chest. 2016 Sep 1;150(3):563-71. https://doi.org/10.1016/j.chest.2016.05.007.
  • Goodale T, Sadhu A, Petak S, Robbins R. Testosterone and the Heart. Methodist DeBakey cardiovascular journal. 2017 Apr;13(2):68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512682/.
  • Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2010 Jun 1;95(6):2536-59. https://doi.org/10.1210/jcem.95.8.9995.

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